Inquiry based drug analysis for the high school classroom. Aug 06, 2015 this video explains in detail about the synthesis of aspirin in the bioorganic chemistry laboratory for the biotechnology students. How do you account for the smell of vinegar when an old bottle of aspirin is opened. Synthesis and biological activity of aspirin derivatives. Be sure to consult the procedure for the detailed instructions. Aspirin serves as the acetylating agent where an acetyl group is covalently attached to a serine. Compound molecular weight hazards density melting point salicylic acid 8. Round calculated values to the proper number of significant figures for each value you are asked to report. Pdf this aim of this experiment focuses on the synthesis of pure aspirin. Synthesis of aspirin derivatives was prepared by esterification in the presence. Aspirin alters the oxygenase activity of prostaglandin synthetase by moving the acetyl group to a terminal amine group4. Crystallization is the process of arranging atoms or molecules in a liquid state into an ordered solid state.
Jan 25, 2018 aspirin recrystallization the crude product of acetylsalicylic acid crystals were placed in a 125 ml erlenmeyer flask and diethyl ether, heated on a steam bath, was added dropwise, while swirling, until all crystals had dissolved. Acetyl salicylic acid, commonly known as aspirin, is one of the most common synthetic medicines. Though aspirin has numerous benefits, there are several adverse affects as well. Postu department of chemistry, american university, washington, d. Why would it not be a satisfactory catalyst in this reaciton. Aspirin was patented by bayer in 1893aspirin is one of the oldest and most consumed drugs production in the us is 10 million kg of aspirin per year. Synthesis of aspirin lab report chm2210 usf studocu. Nov 18, 20 after the synthesis of aspirin, the product was recrystallized for purification to rid the product of impurities. The synthesis of aspirin procedure steps 3 5 were repeated twice more for two more titrations. Aspirin can be made by reacting salicylic acid with acetic acid in the presence of an acid catalyst.
It is carried out to form ester from an acid and an alcohol. The reaction used for this synthesis begins with an excess of acetic acid anhydride c 4 h 6. For the synthesis of aspirin, how do you calculate the. Synopsis the objective of this experiment is to enable us to conduct the synthesis of aspirin, reinforce the skills of recrystallisation an. Experiment 22 synthesis of aspirin and oil of wintergreen. Aspirin recrystallization the crude product of acetylsalicylic acid crystals were placed in a 125 ml erlenmeyer flask and diethyl ether, heated on a steam bath, was added dropwise, while swirling, until all crystals had dissolved. Note that in this reference spectrum, the solvent peak at 77 ppm has been artificially removed.
Environmental education resources to commemorate earth days 50th anniversary. Jan 25, 2018 aspirin is a drug that is usually used to relieve minor aches and pain and other medical uses such as antiinflammatory medication. Acetylsalicylic acid also known as aspirin is a salicylate drug, often used as an analgesic, antipyretic and antiinflammatory medication. Aspirin synthesis lab report by alissa lockwood on prezi. Experiment 11 synthesis and analysis of aspirin introduction aspirin is most widely sold overthecounter drug. Even so, to be able to analyse the composition of an aspirin sample or the amount of acetylsalicylic acid, the hydrolysis of the sample by alkali into neutrality is required. Aspirin is used medically to reduce fever and pain. This is a lab report on the synthesis of organic aspirin.
The purpose of this experiment is to create aspirin by reacting salicylic acid with acetic anhydride. Again, this was a completely new expiriment, hence more pills could be made in the future if the problems we ran into are resolved the next time this expiriment is performed. Calculate the mass of crude aspirin that you collected. A but not 100%, and as such its content is being determined by methods of titration in this experiment, using the indicator phenolpthalein. I doubt you will find an exact source, though these sites will help you in the experiment. Acetic anhydride is uses as it is cheap and forms a byproduct, acetic acid which is not corrosive and can be recovered to make more acetic anhydride unlike other acetylating agents that also can be used. Next, we have to prepare recrystallisation of aspirin.
Aspirin moves through the body until it reaches the small intestine. Below are many of the experimental steps you will perform in this lab. The aspirin synthesized in this experiment will be crystallized from solution. Synthesis and recrystallization of aspirin lab report. Ch 348 physical chemistry spring 2009 mk bowman adapted. The solution was cooled slowly to room temperature, then transferred to an icewater bath. You will need to add up molar masses by counting the atoms shown in the structures. This experiment will layout the steps to synthesize aspirin acetylsalicylic acid, c 9 h 8 o 4. This is the second of two weeks related to aspirin. Solvent suitable for this recrystallisation process is a mixture of ethanol and water. Data, results, references, discussion and conclusions section. View lab report aspirin lab from chem 053 at university of pennsylvania. Chemistry 51 experiment 11 synthesis and analysis of aspirin.
The crude product aspirin prepared is relatively impure and may be purified by recrystallisation. All minor components described in the how to write a strong lab report general guidelines note that the only chemical characterization test results you need report on are for the ferric chloride test. This video is prepared by the 20142018 batch students of p. Pdf preparing a pure aspirin acetylsalicylic acid researchgate. Since acetic acid is very soluble in water, it is easily separated from the aspirin product. Synthesis of aspirin pre lab assignment study the sections related to stoichiometry and limiting reactant in your textbook. For preparation of aspirin, acetic anhydride is added to the measured amount of salicylic acid. Aspirin is a drug that is usually used to relieve minor aches and pain and other medical uses such as antiinflammatory medication. Each collaborative team determines the rate constant for the hydrolysis of aspirin. Aspirin is actually a naturally occurring compound, which can be derived from the bark of willow trees. The purpose of this lab is to synthesize and characterize high purity aspirin. Stephanie farrell objectives to describe how accelerated stability testing at elevated temperatures can be used to explain the stability of the product at room temperature. However, the employer of hoffman, friedrich bayer named and patented the product.
One of the most consumed drugs production in the us is 10 million. The main procedures are preparation of aspirin, recrystallisation of aspirin and lastly determining the melting point of the aspirin. Lab report synthesis and characterization of aspirin acetylsalicylic acid the synthesis and characterization of aspirin acetylsalicylic acid. Remote work advice from the largest allremote company. View notes aspirin synthesis lab report from chem 106 at case western reserve university. Synthesis of aspirin acetylsalicylic acid objectives aspirin, the wonder drug, is an important chemical worldwide. This is a lab report on the synthesis of organic aspirin for first year chemistry. An introduction to physical chemistry chem 10 academic year. It is effective in reducing pain it is an analgesic, reducing inflammation antiinflammatory, reducing fever antipyretic, and thinning blood anticoagulant. This study was carried out to investigate the synthesis of aspirin derivatives from aspirin and aromatic compound of antioxidant and its biological activities. In the presence of moisture, aspirin may decompose hydrolysis into salicylic acid and acetic acid. Lab report the report for this experiment is an abbreviated lab report and need only include. It has the ability to reduce fever an antipyretic, to reduce pain an analgesic, and to reduce swelling, soreness, and redness an antiinflammatory agent. This author provides an excellent student lab report format, explains how it adapts to different science disciplines, and suggests simple labs to familiarize students with it.
Aspirin is an ester that has high molecular weight and it not soluble in water hence the solid can be separated by crystallization process. Synthesis of aspirin acetylsalicylic acid ferric chloride test for salicylic acid. To view pdf files you will need the acrobat viewer available from adobe. The aspirin product is not very soluble in water so the aspirin product will precipitate when water is added. Hydrochloric acid is about as storng a mineral acid as sulfuric acid. For the synthesis of aspirin, how do you calculate the percent yield if the reaction produces 4. Quantitative analysis of aspirin further analysis conclusion the overall objectives of. Let this material sit at room temperature until the next lab period when you will determine your aspirin recovery. After synthesis and analysis, it will be determined if the crude and recrystallized samples were composed solely of either salicylic acid, acetylsalicylic acid, or a combination of both 3. How to classify reactions as zero, first, and second order reactions and their corresponding reactions rates. Aspirin synthesis your team of scientists has been hired by the drug research division of santa monica pharmaceuticals, a new startup company formed by some smc alumni. Recently, it was elucidated that aspirin have anticoaggregatory effect in low dose.
Synthesis and recrystallization of aspirin lab report uk essays. Compare the melting points of your aspirin and pure aspirin. This reaction is the reverse of the synthesis reaction. The purpose of this experiment is to create aspirin by. Aspirin is primarily used to treat pain as well as to avert cardiovascular disease. Report the theoretical yield and the percent yield of the aspirin product. Aspirin has been widely used as analgesic and antiinflammatory drug. Aspirin acetylsalicylic acid is a painrelieving compound.
Crystallization will be induced by scratching the glass beaker to create nuclei around which aspirin may crystallize. The hydrolysis of aspirin into salicylic acid and acetate takes place in the stomach and the. The crude product was dissolved in approximately 5ml of ethanol in a 100ml conical flask. In this lab, you are going to synthesize a very popular and widely used medicinal drug, aspirin acetylsalicylic acid. One of the most consumed drugs production in the us is 10 million kgyear aspirin. Give the balanced equation for the synthesis of aspirin, drawing the structures by hand. It is a derivative of salicylic acid which is also an. Take a small amount of the aspirin tablet and dissolve as much as you can in 3 drops of ethyl acetate. The beerlambert law often shortened to beers law relates the absorbance of a sample to the concentration of. Simplified c nmr correlation table c peak position type of carbon.
Experiment 22 synthesis of aspirin and oil of wintergreen goals. Learn vocabulary, terms, and more with flashcards, games, and other study tools. Synthesis of aspirin experiment chemistry libretexts. This aim of this experiment focuses on the synthesis of pure aspirin acetylsalicylic acid from ethanoic anhydride and salicylic acid while using concentrated sulfuric acid as a catalyst for the. Synthesis of aspirin lab report and analysis odinity. If you need guidance, follow the steps in the report sheets. The crude product and the purified product can be tested using ferric chloride. Aug 08, 2016 synthesis of aspirin lab report essay example for free newyorkessays database with more than 65000 college essays for studying. Quantitative determination of acetylsalicylic acid in. The synthesis of a medicinal agent aspirin by walter scharf and charles malerich natural scienceschemistry baruch college new york, ny 10010 introduction salicylicacidcontaining compounds derived from willow bark have been in use for hundreds of years as antipyretic feverreducing, analgesic pain killing, and antiinflammatory agents. Report data collected and subsequent calculations to all equipment should be returned to. The methods used included recrystallization and scratching to produce a precipitate, which was then filtered to remove any excess moisture.
The temperature of an alcohol thermometer was equilibrated in a beaker of room temperature tap water. Aspirin was first isolated by felix hoffmann, a chemist with the german company bayer in 1897. First discovered in 1897 by felix hoffman, it has since been used in over 50 overthecounter medicines. Synthesis of aspirin lab report essay example for free newyorkessays database with more than 65000 college essays for studying. The aspirin isolated in this step is the crude product. Mar 17, 2014 lab report synthesis and characterization of aspirin acetylsalicylic acid the synthesis and characterization of aspirin acetylsalicylic acid. Exp 3 synthesis of aspirin formal lab report essay. Take a small amount of the salicylic acid sa starting material and dissolve as much as you can in 3 drops of ethyl acetate. Do not lose this container or its contents, you will use them later. Essay by puner, a, february 2008 download word file, 6 pages download word file, 6 pages 5. Aspirin, a drug widely known for its analgesic, antipyretic, and antiinflammatory properties, is a compound derived from two acids namely acetic acid and salicylic acid. You will need to use that spectrum as part of your lab report. The main objective of the synthesis of aspirin lab was so produce aspirin acetylsalicylic acid through the reaction of salicylic acid and acetic anhydride. The ability of aspirin to diminish inflammation is apparently due to its inhibition of the synthesis of prostaglandins, a group of c20 molecules that enhance inflammation.
Based on the mass of salicylic acid 2 g determine the maximum yield of aspirin theoretical. These questions are related to a lab experiment on the synthesis of acetylsalicylic acid aspirin. For this reason, aspirin is often combined with a buffering agent. There are two types of methanol in the lab, make sure that the spectrometric grade methanol is used, the other type of methanol is only good for uv readings at wavelengths lower then 210. Aspirin synthesis tap water was heated on a steam bath in a 250 ml beaker.
Acetylsalicylic acid can irritate musosa in the gastrointestinal tract causing problems such as gastrointestinal bleeding, heart burn. Synthesis and recrystallization of aspirin trial 1 mass of salicylic acid g 2. A major impurity that could be found in the crude product would be unreacted salicylic acid. Preparation of aspirin experiment 5 introduction in this experiment you will prepare a sample of aspirin, recrystallize the raw product, and determine the percentage yield of the aspirin based on the limiting reactant. The main purpose of this lab is to obtain aspirin through the chemical synthesis of salicylic acid by acetylation with acetic anhydride and crystallization. This author provides an excellent student labreport format, explains how it adapts to different science disciplines, and suggests simple labs to familiarize students with it. Preparation and standardization of hcl procedure part 4. Synthesis of aspirin inquiry based drug analysis for. This laboratory introduces students to aspects of practical organic chemistry including synthesis, crystallization, stoichiometry, and percent yield. In this twoweek experiment the important area of organic chemistry will be illustrated by the preparation and characterization of two compounds. Weigh 200 mg of aspirin and add the powder to a 100 ml volumetric flask.
Over history, many compounds obtained from nature have been used to cure ills or to produce an effect in humans. Enteric coatings are used on medications that are irritants to the stomach lining. The usefulness of functional groups will be illustrated as well as the use of nmr, ir, and melting point in characterizing a product. Keep one to two extra digits in your calculation steps. Native americans would chew the bark or grind it into a powder to ingest to relieve pain. Ch 348 physical chemistry spring 2009 mk bowman adapted from. Aspirin synthesis lab report by eddie zhang on prezi. The success of aspirin is said give the foundation of the modern pharmaceutical industry. Salicylic acid, the main metabolite of aspirin, is an integral part of human and animal metabolism. Calculate the percent yield of aspirin amount collected theoretical yield x 100% what is the melt point of your dried aspirin.
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